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Western blot analysis of extracts from COS7 cells treated with Etoposide using Arrestin 1 (Phospho-Ser412) Antibody. The lane on the right is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Arrestin 1 (Phospho-Ser412) antibody (left) or the same antibody preincubated with blocking peptide (right).
Western blot analysis of extracts from COS7 cells treated with Etoposide using Arrestin 1 (Phospho-Ser412) Antibody. The lane on the right is treated with the antigen-specific peptide.

Arrestin 1 (phospho Ser412) Antibody

CATALOG NUMBER: 79-784

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Arrestin 1 (phospho Ser412) antibody was raised against a peptide sequence around phosphorylation site of Serine 412 (T-G-S (p)-P-Q) derived from Human Arrestin 1.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
The antibody detects endogenous levels of Arrestin-1 only when phosphorylated at serine 412.
Predicted Molecular Weight:
50 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
ARRB1
Additional Names:
ARR1, arrestin 2, arrestin beta 1, beta-arrestin-1
Protein Accession Number:
NP_004032.2
Protein Gi Number:
10880136
Ncbi Gene Id Number:
408
Background:
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.
Background Reference 1:
Greg Buchanan. AACR Meeting Abstracts, Apr 2006; 2006: 430.
Background Reference 2:
D. Alex Groarke. Mol. Pharmacol., Feb 2001; 59: 375.
Background Reference 3:
Karen McConalogue. Mol. Biol. Cell, Aug 1998; 9: 2305.
Background Reference 4:
Maria Stella Lombardi. Stroke, Apr 2004; 35: 981 - 986.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-784

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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