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Human ASGR1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Human ASGR1, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

ASGR1 / ASGPR1 Recombinant Protein

CATALOG NUMBER: 11-154

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 62 - Leu 291
Fusion Tag:
Fc Tag
Tested Applications:
WB
Application Note:
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 52.8 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
52.8 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
ASGR1
Additional Names:
ASGP-R 1, ASGPR 1, C-type lectin domain family 4 member H1, Hepatic lectin H1, HL-1
Protein Accession Number:
NP_001662.1
Ncbi Gene Id Number:
432
Background:
ASGPR, a transmembrane C-type lectin, recognizes a wide variety of ligands that contain either terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues and has been identified as a highly selective receptor on hepatocytes. The ASGR is composed of both a major (ASGR1) and minor subunit (ASGR2). ASGR1 has been shown to be efficiently targeted to the plasma membrane and to undergo constitutive endocytosis and recycling and found mainly expressed in the human liver.
Background Reference 1:
Bon C. et al., MAbs. 2017 Nov; 9(8): 1360–1369.
Background Reference 2:
Tanowitz M. et al., Nucleic Acids Res. 2017 Dec 1; 45(21): 12388–12400.
Background Reference 3:
Shi B. et al., J Histochem Cytochem. 2013 Dec; 61(12): 901–909.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-154

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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