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ATF-2 (phospho Ser472) Antibody

CATALOG NUMBER: 79-895

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
ATF-2 (phospho Ser472) antibody was raised against a peptide sequence around phosphorylation site of Serine 472 (E-A-V (p)-A-T) derived from Human ATF-2.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of ATF-2 only when phosphorylated at serine 472.
Predicted Molecular Weight:
54 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
ATF2
Additional Names:
Activating 2, ATF2, cAMP response element binding protein CRE- BP1, CREB2, HB16
Protein Accession Number:
NP_001243019.1
Protein Gi Number:
22538422
Ncbi Gene Id Number:
1386
Background:
Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
Background Reference 1:
Maekawa T., EMBO J. 8:2023-2028(1989).
Background Reference 2:
Yang L., J. Immunol. 158:2522-2525(1997).
Background Reference 3:
Kara C.J., Mol. Cell. Biol. 10:1347-1357(1990).

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-895

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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