ATP2B4 Antibody

Background:

The protein encoded by this gene belongs to the family ofP-type primary ion transport ATPases characterized by the formationof an aspartyl phosphate intermediate during the reaction cycle.These enzymes remove bivalent calcium ions from eukaryotic cellsagainst very large concentration gradients and play a critical rolein intracellular calcium homeostasis. The mammalian plasma membranecalcium ATPase isoforms are encoded by at least four separate genesand the diversity of these enzymes is further increased byalternative splicing of transcripts. The expression of differentisoforms and splice variants is regulated in a developmental,tissue- and cell type-specific manner, suggesting that these pumpsare functionally adapted to the physiological needs of particularcells and tissues. This gene encodes the plasma membrane calciumATPase isoform 4. Alternatively spliced transcript variantsencoding different isoforms have been identified. [provided byRefSeq].