ATP5G1 Antibody

Background:

This gene encodes a subunit of mitochondrial ATP synthase.Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing anelectrochemical gradient of protons across the inner membraneduring oxidative phosphorylation. ATP synthase is composed of twolinked multi-subunit complexes: the soluble catalytic core, F1, andthe membrane-spanning component, Fo, comprising the proton channel.The catalytic portion of mitochondrial ATP synthase consists of 5different subunits (alpha, beta, gamma, delta, and epsilon)assembled with a stoichiometry of 3 alpha, 3 beta, and a singlerepresentative of the other 3. The proton channel seems to havenine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one ofthree genes that encode subunit c of the proton channel. Each ofthe three genes have distinct mitochondrial import sequences butencode the identical mature protein. Alternatively splicedtranscript variants encoding the same protein have been identified.