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Human B7-H3 (4Ig), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human B7-H3 (4Ig), Fc Tag at 2 ug/mL (100 uL/well) can bind Monoclonal Anti-Human B7-H3 / B7-H3 (4Ig) Antibody, Human IgG1 with a linear range of 0.3-5 ng/mL (QC tested).
Human B7-H3 (4Ig), Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

B7-H3 (4Ig) / B7-H3b Recombinant Protein

CATALOG NUMBER: 11-423

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gly 27 - Thr 461
Fusion Tag:
Fc Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 73.1 kDa. The protein migrates as 100-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
73.1 kDa
Purity:
>95% as determined by reduced SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
CD276
Additional Names:
4Ig-B7-H3,B7-H3,CD276,PSEC0249,UNQ309/PRO352,B7 homolog 3
Protein Accession Number:
NP_001019907.1
Ncbi Gene Id Number:
80381
Background:
Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V-like and Ig C-like domains with a short cytoplasmic tail. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V-type and one C-type) and shows a ubiquituous expression pattern.
Background Reference 1:
Chapoval AI., et al. 2001, Nat Immunol., 2(3), 269-74.
Background Reference 2:
Steinberger P., et al. 2004, J Immunol., 172(4), 2352-9.
Background Reference 3:
Sun M., et al. 2002, J Immunol., 168(12), 6294-7.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-423

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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