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Cynomolgus B7-H6 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Immobilized Human NKp30, Fc Tag at 5 ug/mL (100 uL/well) can bind Cynomolgus B7-H6 with a linear range of 0.625-5 ug/mL (QC tested).
Cynomolgus B7-H6 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

B7-H6 / NCR3LG1 Recombinant Protein

CATALOG NUMBER: 11-451

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Cynomolgus monkey
source-species:
HEK293 cells
Recombinant Protein Sequence:
Asp 25 - Asp 259
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
28.4 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
NCR3LG1
Additional Names:
B7-H6,NCR3LG1,B7 Homolog 6
Protein Accession Number:
XP_005578557.1
Ncbi Gene Id Number:
102121659
Background:
The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
Background Reference 1:
Wu MR, et all., 2015, Gene Ther. 22(8):675-84.
Background Reference 2:
Phillips M, et all., 2016, Biopolymers. 106(5):658-72.
Background Reference 3:
Flajnik MF, et all., 2012 Immunogenetics. 64(8):571-90.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-451

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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