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Human B7-H7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human CD28H, Fc Tag at 5 ug/mL (100 uL/well) can bind Human B7-H7, His Tag with a linear range of 0.02-0.313 ug/mL (QC tested).
Immobilized Human B7-H7, His Tag at 5 ug/mL (100 uL/well) can bind Human CD28H, Fc Tag with a linear range of 1-20 ng/mL (Routinely tested).
Human B7-H7, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

B7-H7 / HHLA2 Recombinant Protein

CATALOG NUMBER: 11-384

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ile 23 - Asn 344
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 38.9 kDa. The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
38.9 kDa
Purity:
>90% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
HHLA2
Additional Names:
B7-H7,HHLA2,B7 Homolog 7
Protein Accession Number:
NP_009003.1
Ncbi Gene Id Number:
11148
Background:
B7-H7 (HHLA2) is a newly identified B7 family member that regulates human T-cell functions. B7-H7 was previously known as human endogenous retrovirus-H long terminal repeat associating 2 (HHLA2) with unidentified function. Recently, B7-H7 has been identified as a specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promoted CD4+ T-cell proliferation and cytokine production via an AKT-dependent signaling cascade in the presence of TCR signaling, suggesting B7-H7 comprises a new co-stimulatory pathway. The first IgV domain of B7-H7, which presumably binds to a putative receptor, shows the highest homology to other B7 family members.
Background Reference 1:
Ni L., et al., 2017, Mol. Cancer. Ther. 16:1203-1211.
Background Reference 2:
Jung K., et al., 2013, Immune. Netw. 13:184-193.
Background Reference 3:
Janakiram M., et al., 2015, Clin. Cancer. Res. 21:2359-2366.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-384

List Size:
0.1 mg

List Price:

$515.00

Out of stock

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