Bax (phospho Thr167) Antibody

CATALOG NUMBER: 79-802

Clonality:
Polyclonal
Tested Applications:
IF
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Bax (phospho Thr167) antibody was raised against a peptide sequence around phosphorylation site of threonine167 (P-G-T (p)-P-T) derived from Human Bax.
Conjugate:
Unconjugated
Tested Applications:
IF
Specificity:
The antibody detects endogenous levels of Bax only when phosphorylated at threonine 167.
Predicted Molecular Weight:
21 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
BAX
Additional Names:
BAXA, Apoptosis regulator BAX, membrane isoform alpha, Bcl2-associated X protein
Protein Accession Number:
NP_620116.1
Protein Gi Number:
388166
Ncbi Gene Id Number:
581
Background:
Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Background Reference 1:
Francesca Andriani. J Natl Cancer Inst, Sep 2001; 93: 1314 - 1324.
Background Reference 2:
H Martinez-Valdez. J. Exp. Med., Mar 1996; 183: 971.
Background Reference 3:
Joslyn K. Brunelle. J. Biol. Chem., Feb 2004; 279: 4305 - 4312.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-802

List Size:
0.1 mg

List Price:

$376.00

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