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Western blot analysis of lysed extracts from MCF cells using BCL-2 (Ab-70).
<b>Top Image:</b> Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BCL-2 (Ab-70).<b>Bottom Image:</b> Immunofluorescence staining of methanol-fixed HeLa cells using BCL-2 (Ab-70).
Western blot analysis of lysed extracts from MCF cells using BCL-2 (Ab-70).

BCL 2 (Ab 70) Antibody

CATALOG NUMBER: 79-299

Clonality:
Polyclonal
Tested Applications:
IF, IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
BCL-2 (Ab-70) antibody was raised against a peptide sequence around aa.68~72 (R-T-S-P-L) derived from Human BCL-2.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Specificity:
This antibody detects endogenous level of total BCL-2 protein.
Predicted Molecular Weight:
26 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
BCL2
Additional Names:
Bcl-2, PPP1R50, PKR, PRKR, BCL2
Protein Accession Number:
NP_000624.2
Protein Gi Number:
72198189
Ncbi Gene Id Number:
596
Background:
BCL-2 encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Background Reference 1:
Muller IM, et al. (2005) Mol Pharmacol. Jin Z, Gao F, et al. J Biol Chem 2004 Sep 17; 279 (38): 40209-19. Kumar Biswas S, et al. Mol Cancer Ther 2004 Mar; 3 (3): 327-34. Huang ST, et al. (2002) FASEB J; 16 (8): 825-32. Yamamoto K, et al. (1999) Mol Cell Biol; 19 (12): 8469-78.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-299

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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