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Western blot analysis of lysed extracts from 293 and HeLa cells using BCL-XL (Ab-62).
Western blot analysis of lysed extracts from 293 and HeLa cells using BCL-XL (Ab-62).

BCL XL (Ab 62) Antibody

CATALOG NUMBER: 79-525

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
BCL-XL (Ab-62) antibody was raised against a peptide sequence around aa.60~64 (A-D-S-P-A) derived from human BCL-XL .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
This antibody detects endogenous level of total BCL-XL protein.
Predicted Molecular Weight:
30 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
BCL2L1
Additional Names:
BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S, P53, Apoptosis regulator Bcl-X
Protein Accession Number:
NP_612815.1
Protein Gi Number:
20336335
Ncbi Gene Id Number:
598
Background:
Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.
Background Reference 1:
Basu A, et. al. ( 2003) Mar 13; 538 (1-3): 41-7Cheng E. H. -Y. et. al. (1996) Nature 379:554-556. Sattler M. et. al. (1997) , Science 275:983-986. Muchmore S. W. et. al (1996) . Nature 381:335-341Yu J., Zhang L. Mol. (2001) Cell 7:673-682

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-525

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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