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Human Bcl-x, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.
Human Bcl-x, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 92%.

BCL2L1 Recombinant Protein

CATALOG NUMBER: 96-056

Tested Applications:
WB
Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
Met 1 - Arg 212
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
24.6 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human BID protein at 10μg/ml (100μl/well) can bind biotinylated human BCL2L1 protein, The EC50 of biotinylated human BCL2L1 is 6. 5 ng/mL.
Purity:
>92% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
20mM HEPES, 50mM KCl, pH 7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
BCL2L1
Additional Names:
BCL2L1, Bcl-XL, Bcl2-L-1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, bcl-xS
Protein Accession Number:
AAH19307
Ncbi Gene Id Number:
598
Background:
Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
Background Reference 1:
Terrano D.T., et al., 2010, Mol. Cell. Biol. 30:640-656.
Background Reference 2:
Wang J., et al., 2011, Cell. Signal. 23:2030-2038.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-056

List Size:
0.1 mg

List Price:

$495.00

Datasheet
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