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Western blot analysis of BCL3 in 293 cell lysate with BCL3 antibody at 1 μg/mL.
Western blot analysis of BCL3 in 293 cell lysate with BCL3 antibody at 1 μg/mL.
Trial Size

BCL3 Antibody

CATALOG NUMBER: 7183

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Rabbit polyclonal BCL3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human BCL3.
The immunogen is located within amino acids 360 - 410 of BCL3.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
BCL3 antibody can be used for detection of BCL3 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1210 - HEK293 Cell Lysate
Predicted Molecular Weight:
Predicted: 50 kDa
Purification:
BCL3 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
BCL3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
BCL3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
BCL3
Additional Names:
BCL3 Antibody: BCL4, D19S37, BCL4, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL-3
Protein Accession Number:
NP_005169
Protein Gi Number:
164664508
Ncbi Gene Id Number:
602
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
BCL3 Antibody: The proto-oncogene Bcl-3, believed to be involved in certain human B cell leukemias, encodes a protein that contributes to the regulation of transcriptional activation of NF-κ-B target genes. BCL3 contains seven ankyrin repeats, which are most closely related to those found in I-κ-B proteins. The expression of this gene can be induced by NF-κ-B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-κ-B. It contributes to the regulation of cell proliferation. A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia.
Background Reference 1:
Ohno H, Takimoto G, and McKeithan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 1990; 60:991-7.
Background Reference 2:
Wulczyn FG, Naumann M, and Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature 1992; 358:597-9.
Background Reference 3:
Ibrahim HA, Amen F, Reid AG, et al. BCL3 rearrangement, amplification and expression in diffuse large B-cell lymphoma. Eur. J. Haematol. 2011; 87:480-5.
Background Reference 4:
Ge B, Li O, Wilder P, et al. NF-kappa B regulates BCL3 transcription in T lymphocytes through an intronic enhancer. J. Immunol. 2003; 171:4210-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7183

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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