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BDNF Recombinant Protein

CATALOG NUMBER: 40-496

Specifications
source-species:
E. coli
Species:
Human, Mouse, Rat
source-species:
E. coli
Recombinant Protein Sequence:
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Biological Activity:
Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized BDNF recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted BDNF is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing BDNF recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
BDNF
Additional Names:
ANON2, BULN2, Brain-derived neurotrophic factor, Abrineurin, BDNF
Protein Accession Number:
NP_001137277.1
Protein Gi Number:
219842288
Ncbi Gene Id Number:
627
Background:
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-496

List Size:
0.002 mg, 0.01 mg

List Price:

Price range: $199.00 through $305.00

Datasheet
Shipping Info

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