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BimS/EL/L Antibody [3C5]

CATALOG NUMBER: 36-185

Clonality:
Monoclonal
Tested Applications:
ELISA, Flow, ICC, IHC, IP, WB
Host Species:
Rat
Species Reactivity:
Dog, Human, Monkey, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Dog, Human, Monkey, Mouse, Rat
Immunogen:
Synthetic peptide corresponding to aa 20-40 of mouse BimL.
Conjugate:
Unconjugated
Tested Applications:
ELISA, Flow, ICC, IHC, IP, WB
Application Note:
ChIP: (1:200) Band shift assay: Competes with probe for NFAT binding. . Immunoprecipitation: (1:200) . Western Blot: (1:500-1:1000) . Optimal conditions must be determined individually for each application.
Specificity:
Recognizes an epitope within aa 20-40 of human, mouse, rat, monkey and dog BimL (~19kDa), BimEL (~23kDa), and BimS (~16kDa). Also recognizes the six novel isoforms of human Bim, generated by alternative splicing and lacking the C-terminal hydrophobic region.
Purification:
>95% (SDS-PAGE)
Clonality:
Monoclonal
Isotype:
IgG2a, kappa
physical-state:
Liquid
Buffer:
Liquid. In PBS containing 0.02% sodium azide and 25% glycerol.
Concentration:
1 mg/ml
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C.
Additional Names:
BCL2L11; Bcl-2-like Protein 11; Bcl2-interacting Mediator of Cell Death
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Bim belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family (BCL2, BCL2L1/BCL-X(L) and MCL1) and to act as an apoptotic activator, inducing apoptosis and anoikis. Several variants have been identified. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

36-185

List Size:
100 ug

List Price:

$498.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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