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Western blot analysis of extracts from COLO205 tissue using BLNK (Phospho-Tyr96) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from COLO205 tissue using BLNK (Phospho-Tyr96) Antibody. The lane on the right is treated with the antigen-specific peptide.

BLNK (phospho Tyr96) Antibody

CATALOG NUMBER: 80-013

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
BLNK (phospho Tyr96) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 96 (D-S-Y (p)-E-P) derived from Human BLNK .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of BLNK only when phosphorylated at tyrosine 96.
Predicted Molecular Weight:
50 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
BLNK
Additional Names:
B-cell linker protein, LY57, SLP-65, SLP65,
Protein Accession Number:
NM_001114094.1
Protein Gi Number:
7019535
Ncbi Gene Id Number:
29760
Background:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling.
Background Reference 1:
Wang X, et al. (2012)J Biol Chem 287, 11037-48. Patterson HC, et al. (2006)Immunity 25, 55-65 . Chiu CW, et al. (2002)EMBO J 21, 6461-72.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

80-013

List Size:
0.1 mg

List Price:

$355.00

Out of stock

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