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Western blot analysis of extracts from 293 cells using BRCA2 (Phospho-Ser3291) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from 293 cells using BRCA2 (Phospho-Ser3291) Antibody. The lane on the right is treated with the antigen-specific peptide.

BRCA2 (phospho Ser3291) Antibody

CATALOG NUMBER: 79-949

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
BRCA2 (phospho Ser3291) antibody was raised against a peptide sequence around phosphorylation site of Serine 3291 (F-V-S (p)-P-A) derived from Human BRCA2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous levels of BRCA2 only when phosphorylated at serine 3291.
Predicted Molecular Weight:
>350 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
BRCA2
Additional Names:
BRCC2, BRCA2, subunit 2, BRCA1/BRCA2-containing complex
Protein Accession Number:
NP_000050.2
Protein Gi Number:
14424438
Ncbi Gene Id Number:
675
Background:
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.
Background Reference 1:
Wooster R., Nature 378:789-792(1995).
Background Reference 2:
Tavtigian S.V., Nat. Genet. 12:333-337(1996).
Background Reference 3:
Dunham A., Nature 428:522-528(2004).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-949

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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