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BTNL2 Recombinant Protein

CATALOG NUMBER: 90-375

Specifications
source-species:
CHO cells
Species:
Mouse
source-species:
CHO cells
Recombinant Protein Sequence:
The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a.
Fusion Tag:
Fc Tag
Application Note:
This recombinant proteins is for research use only.
Biological Activity:
A butyrophilin-like molecule that functions to inhibit T cell activation.
Purity:
>98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
physical-state:
Lyophilized
Buffer:
Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
Storage Conditions:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Ncbi Official Symbol:
Btnl2
Additional Names:
Butyrophilin-like Protein 2
Protein Accession Number:
NP_524574
Protein Gi Number:
83721945
Ncbi Gene Id Number:
547431
Background:
Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis; to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

90-375

List Size:
100 ug

List Price:

$540.00

Datasheet
Shipping Info

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Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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