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Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
C10orf2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).

C10orf2 Antibody

CATALOG NUMBER: 56-653

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This C10orf2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-684 amino acids from the C-terminal region of human C10orf2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
77 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
PEO1
Additional Names:
Twinkle protein, mitochondrial, Progressive external ophthalmoplegia 1 protein, T7 gp4-like protein with intramitochondrial nucleoid localization, T7-like mitochondrial DNA helicase, PEO1, C10orf2
Protein Accession Number:
Q96RR1
Protein Gi Number:
74752111
Ncbi Gene Id Number:
56652
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a hexameric DNA helicase which unwindsshort stretches of double-stranded DNA in the 5' to 3' directionand, along with mitochondrial single-stranded DNA binding proteinand mtDNA polymerase gamma, is thought to play a key role in mtDNAreplication. The protein localizes to the mitochondrial matrix andmitochondrial nucleoids. Mutations in this gene cause infantileonset spinocerebellar ataxia (IOSCA) and progressive externalophthalmoplegia (PEO) and are also associated with severalmitochondrial depletion syndromes. Alternative splicing results inmultiple transcript variants encoding distinct isoforms.
Background Reference 1:
Longley, M.J., et al. J. Biol. Chem. 285(39):29690-29702(2010)
Background Reference 2:
Wang, W., et al. Nucleic Acids Res. (2010) In press :
Background Reference 3:
Fratter, C., et al. Neurology 74(20):1619-1626(2010)
Background Reference 4:
Kruger, J., et al. Mol Neurodegener 5,(2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-653

List Size:
400 ul

List Price:

$495.00

Datasheet
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