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CAD (phospho Thr456) Antibody

CATALOG NUMBER: 79-899

Clonality:
Polyclonal
Tested Applications:
IHC
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
CAD (phospho Thr456) antibody was raised against a peptide sequence around phosphorylation site of threonine 456 (P-I-T (p)-P-H) derived from Human CAD.
Conjugate:
Unconjugated
Tested Applications:
IHC
Specificity:
The antibody detects endogenous levels of CAD only when phosphorylated at threonine 456.
Predicted Molecular Weight:
242 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
CAD
Additional Names:
PYR1, CAD protein, EC 2.1.3.2, EC 3.5.2.3
Protein Accession Number:
NP_004332.2
Protein Gi Number:
50403731
Ncbi Gene Id Number:
790
Background:
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
Background Reference 1:
Iwahana H., Biochem. Biophys. Res. Commun. 219:249-255(1996).
Background Reference 2:
Davidson J.N., DNA Cell Biol. 9:667-676(1990).
Background Reference 3:
Olsen J.V., Cell 127:635-648(2006).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-899

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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