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Canine CD47, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human SIRP alpha, Fc Tag (HPLC-verified) at 5 ug/mL (100 uL/well) can bind Canine CD47, His Tag with a linear range of 5-78 ng/mL (QC tested).
Canine CD47, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

Canine CD47 Recombinant Protein

CATALOG NUMBER: 11-346

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Dog
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 19 - Asn 140
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.8 kDa. The protein migrates as 27-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
15.8 kDa
Purity:
>90% as determined by reduced SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Names:
CD47,MER6,IAP,OA3
Background:
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
Background Reference 1:
Lindberg F.P., et al., 1993, J. Cell Biol. 123:485-496.
Background Reference 2:
Latour S., et al., 2001, J. Immunol. 167:2547-2554.
Background Reference 3:
Piccio L., et al., 2005, Blood 105:2421-2427.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-346

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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