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Western blot analysis of lysed extracts from 293, HeLa and MDA cells using Caspase 3 Antibody.
Western blot analysis of lysed extracts from 293, HeLa and MDA cells using Caspase 3 Antibody.

Caspase 3 Antibody

CATALOG NUMBER: 79-641

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
Caspase 3 antibody was raised against a peptide sequence around aa.29~33 (S-G-I-S-L) derived from Caspase 3.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:1000
Specificity:
This antibody detects endogenous level of total Caspase 3 protein.
Predicted Molecular Weight:
35 19 17 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
CASP3
Additional Names:
CPP32, SCA-1, CPP32B, SCFR, Apopain
Protein Accession Number:
NP_004337.2
Protein Gi Number:
14790119
Ncbi Gene Id Number:
836
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-, -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Background Reference 1:
Gervais, F. G et al. Cell 97: 395-406, 1999. Nicholson, D. W. et al. (1995) Nature 376, 37-43.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-641

List Size:
0.1 mg

List Price:

$370.00

Datasheet
Shipping Info

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