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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

CBX5 Antibody

CATALOG NUMBER: 57-266

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This CBX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-117 amino acids from the Central region of human CBX5.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
22 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CBX5
Additional Names:
Chromobox protein homolog 5, Antigen p25, Heterochromatin protein 1 homolog alpha, HP1 alpha, CBX5, HP1A
Protein Accession Number:
P45973
Protein Gi Number:
1170338
Ncbi Gene Id Number:
23468
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a highly conserved nonhistone protein,which is a member of the heterochromatin protein family. Theprotein is enriched in the heterochromatin and associated withcentromeres. The protein has a single N-terminal chromodomain whichcan bind to histone proteins via methylated lysine residues, and aC-terminal chromo shadow-domain (CSD) which is responsible for thehomodimerization and interaction with a number ofchromatin-associated nonhistone proteins. The encoded product isinvolved in the formation of functional kinetochore throughinteraction with essential kinetochore proteins. The gene has apseudogene located on chromosome 3. Multiple alternatively splicedvariants, encoding the same protein, have been identified.
Background Reference 1:
Nozawa, R.S., et al. Nat. Cell Biol. 12(7):719-727(2010)
Background Reference 2:
Zeng, W., et al. Epigenetics 5(4):287-292(2010)
Background Reference 3:
Emelyanov, A.V., et al. J. Biol. Chem. 285(20):15027-15037(2010)
Background Reference 4:
Kiyomitsu, T., et al. J. Cell Biol. 188(6):791-807(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-266

List Size:
400 ul

List Price:

$495.00

Datasheet
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