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Western blot analysis of CCDC134 in rat brain tissue lysate with CCDC134 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of CCDC134 in human brain tissue with CCDC134 antibody at 2.5 μg/mL.
Immunofluorescence of CDCC134 in human brain tissue with CDCC134 antibody at 20 μg/mL.
Western blot analysis of CCDC134 in rat brain tissue lysate with CCDC134 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

CCDC134 Antibody

CATALOG NUMBER: 5265

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
CCDC134 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CCDC134.
The immunogen is located within the first 50 amino acids of CCDC134.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
CCDC134 antibody can be used for detection of CCDC134 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1463 - Rat Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Purification:
CCDC134 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
CCDC134 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
CCDC134 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CCDC134
Additional Names:
CCDC134 Antibody: dJ821D11.3, Coiled-coil domain-containing protein 134
Protein Accession Number:
NP_079097
Protein Gi Number:
13376216
Ncbi Gene Id Number:
79879
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
CCDC134 Antibody: The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. One such protein is CCDC134, a recently identified secretory protein that has been found to inhibit the transcriptional activity of the Elk1 protein. Overexpression CCDC134 also inhibited the phosphorylation of Erk and JNK/SAPK but not p38 MAPK, while specific siRNA against CCDC134 activated Elk1 transcriptional activity and the phosphorylation of Erk and JNK/SAPK, suggesting a potential inhibiting role of CCDC134 in MAPK-mediated Elk1 transcription. CCDC134 is widely expressing in normal adult tissues, tumors, and cell lines.
Background Reference 1:
Steinmetz MO, Jelesarov I, Matousek WM, et al. Molecular basis of coiled-coil formation. Proc. Natl. Acad. Sci. USA2007; 104:7062-7.
Background Reference 2:
Huang J, Shi T, Ma T, et al. CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK. Cell. Mol. Life Sci.2008; 65:338-49.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5265

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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