CCL6 Recombinant Protein

CATALOG NUMBER: 96-084

Tested Applications:
WB
Specifications
Source Species:
HEK293 cells
Species:
Mouse
Source Species:
HEK293 cells
Recombinant Protein Sequence:
Gly 22 - Ala 116
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
11.4 kDa
Biological Activity:
Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR1.   The ED50 for this effect is typically 0. 01-0. 15 μg/mL.
Purity:
>95% as determined by SDS-PAGE.
Physical State:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
Ccl6
Additional Names:
CCL6, SCYA6, C10, MRP-1
Protein Accession Number:
P27784
Ncbi Gene Id Number:
20305
Background:
Chemokine (C-C motif) ligand 6 (CCL6), a member of the CC chemokine family, was initially identified as a transcript that is induced in bone marrow cells upon stimulation with GM­CSF. CCL6 has only been identified in rodents, A human homologue for mouse CCL6 has not been identified.  The mCCL6 cDNA encodes a 116 amino acid residue precursor protein with a hydrophobic signal peptide that is cleaved to yield a 95 amino acid residue mature protein. In mice, CCL6 is expressed in cells from neutrophil and macrophage lineages, where it is strongly induced upon GM­CSF (Cat. # GMF-H4214) stimulation. Mouse CCL6 expression was also shown to be strongly induced by IL-4 (Cat. # IL4-H4218) in mouse macrophages and by cytokine IL­13 (Cat. # IL3-H4210) in mouse lung. Mouse CCL6 is located on chromosome 11. The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.
Background Reference 1:
Orlofsky, et al., 1991, Cell Regul. 2 (5), 403-412.
Background Reference 2:
Ma., et al., 2004, J Immunol.172(3):1872-81.
Background Reference 3:
Berger., et al., 1993, DNA Cell Biol. 12 (9), 839-847.
Background Reference 4:
Kanno M, et al., 2005, J Neuroimmunol. 167(1-2): 72-80.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-084

List Size:
0.02 mg

List Price:

$380.00

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