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Western blot analysis of CCR5 in THP-1 whole cell lysate with CCR5 antibody at 1 μg/mL.
Immunohistochemistry of CCR5 in human lymph node tissue with CCR5 antibody at 20 μg/mL.
Immunohistochemistry of CCR5 in human lymph node tissue with CCR5 antibody at 2.5 μg/ml.
Immunofluorescence of CCR5 in human lymph node tissue with CCR5 antibody at 20 μg/mL.<br><br>Green: CCR5 Antibody (1112) <br> Blue: DAPI staining
Western blot analysis of CCR5 in THP-1 whole cell lysate with CCR5 antibody at 1 μg/mL.
Trial Size

CCR5 Antibody

CATALOG NUMBER: 1112

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
CCR5 antibody was raised against a 15 amino acid peptide near the amino terminus of human CCR5.
The immunogen is located within the first 50 amino acids of CCR5.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
CCR5 antibody can be used for Western blot at 1 μg/mL. CCR5 antibody can also detect CCR5 by immunohistochemistry at 2.5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1208 - THP-1 Cell Lysate
Positive Control 2:
Cat. No. 1369 - Human Lymph node Tissue Lysate
Positive Control 3:
Cat. No. 11-521 - Human Lymphoid Tissue Tissue Slide
Predicted Molecular Weight:
Predicted: 39 kDa
Observed: 40 kDa
Purification:
CCR5 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
CCR5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/ml
Storage Conditions:
CCR5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CCR5
Additional Names:
CCR5 Antibody: CKR5, CCR-5, CD195, CKR-5, CCCKR5, CMKBR5, IDDM22, CC-CKR-5, C-C chemokine receptor type 5, CHEMR13, C-C CKR-5
Protein Accession Number:
AAB57793
Protein Gi Number:
2104520
Ncbi Gene Id Number:
1234
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
CCR5 Antibody: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Background Reference 1:
Dimitrov, DS. Cell 1997; 91:721-30
Background Reference 2:
Littman, DR. Cell 1998; 93:677-80
Background Reference 3:
Deng, H, et al. Nature 1996; 381:661-6
Background Reference 4:
Dragic, T, et al. Nature 1996; 381:667-73

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

1112

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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