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CD11a Antibody [M17/4]

CATALOG NUMBER: 76-139

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Rat IgG2a, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Itgal
Additional Names:
Cd11a, LFA-1, Ly-15, Ly-21, (p180), LFA-1A, Itgal
Ncbi Gene Id Number:
16408
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein. CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1). LFA-1 is expressed on all leukocytes and is involved in intercellular adhesions. The M17/4 antibody blocks many of the LFA-1 mediated cell interaction and in vivo it prolongs allograft survival, inhibits the autoimmune response, and reduces graft versus host reactions.
Background Reference 1:
Saban, M. R., Saban, R., Bjorling, D., Haak-Frendscho, M. (1997). Involvement of leukotrienes, TNF-alpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration.Journal of leukocyte biology,61(4), 445-451.
Background Reference 2:
Zhao, Y., Iwata, M. (1995). Cross-linking of the TCRCD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506.International immunology,7(9), 1387-1396.
Background Reference 3:
Kootstra, C. J., Van Der Giezen, D. M., Van Krieken, J. H. J. M., De Heer, E., Bruijn, J. A. (1997). Effective treatment of experimental lupus nephritis by combined administration of antiCD11a and antiCD54 antibodies.Clinical Experimental Immunology,108(2), 324-332.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-139

List Size:
0.05 mg

List Price:

$222.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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