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CD11b (activation epitope) Antibody [CBRM1/5]

CATALOG NUMBER: 76-115

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
ITGAM
Additional Names:
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM
Ncbi Gene Id Number:
3684
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The CBRM1/5 monoclonal antibody binds with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin β2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules. The CBRM1/5 specifically reacts with the activation-specific epitope of the Mac-1 molecule, in the I domain on the alpha chain near the ligand binding site. The antibody has been reported to inhibit the cellular adhesion mediated by Mac-1.
Background Reference 1:
Oxvig, C., Lu, C., Springer, T. A. (1999). Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.Proceedings of the National Academy of Sciences,96(5), 2215-2220.
Background Reference 2:
Diamond, M. S., Springer, T. A. (1993). A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen.The Journal of cell biology,120(2), 545-556.
Background Reference 3:
Shimaoka, M., Shifman, J. M., Jing, H., Takagi, J., Mayo, S. L., Springer, T. A. (2000). Computational design of an integrin I domain stabilized in the open high affinity conformation.Nature Structural Molecular Biology,7(8), 674-678.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-115

List Size:
0.1 mg

List Price:

$540.00

Datasheet
Shipping Info

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