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CD11b Antibody [M1/70]

CATALOG NUMBER: 76-117

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IHC
Host Species:
Rat
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IHC
Specificity:
The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography.
Clonality:
Monoclonal
Isotype:
Rat IgG2b, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
ITGAM
Additional Names:
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM
Ncbi Gene Id Number:
3684
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18). Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
Background Reference 1:
Sanchez-Madrid, F., Simon, P., Thompson, S., Springer, T. A. (1983). Mapping of antigenic and functional epitopes on the alpha-and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.The Journal of experimental medicine,158(2), 586-602.
Background Reference 2:
Ault, K. A., Springer, T. A. (1981). Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells.The Journal of Immunology,126(1), 359-364.
Background Reference 3:
Springer, T., Galfre, G., Secher, D. S., Milstein, C. (1978). Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens.European journal of immunology,8(8), 539-551.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-117

List Size:
0.1 mg

List Price:

$275.00

Datasheet
Shipping Info

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