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CD127 Antibody [A7R34]

CATALOG NUMBER: 76-906

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IHC, IP
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IHC, IP
Specificity:
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2a, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Il7r
Additional Names:
CD127, IL-7Ralpha, Il7r
Ncbi Gene Id Number:
16197
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.
Background Reference 1:
Sudo, T., Nishikawa, S. A. T. O. M. I., Ohno, N. O. R. I. K. O., Akiyama, N. A. O. K. O., Tamakoshi, M. A. S. A. T. A. D. A., Yoshida, H. I. S. A. H. I. R. O. (1993). Expression and function of the interleukin 7 receptor in murine lymphocytes.Proceedings of the National Academy of Sciences,90(19), 9125-9129.
Background Reference 2:
Hashi, H., Yoshida, H., Honda, K., Fraser, S., Kubo, H., Awane, M., ... Nishikawa, S. I. (2001). Compartmentalization of Peyers patch anlagen before lymphocyte entry.The Journal of Immunology,166(6), 3702-3709.
Background Reference 3:
Okuno, Y., Iwasaki, H., Huettner, C. S., Radomska, H. S., Gonzalez, D. A., Tenen, D. G., Akashi, K. (2002). Differential regulation of the human and murine CD34 genes in hematopoietic stem cells.Proceedings of the National Academy of Sciences,99(9), 6246-6251.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-906

List Size:
0.1 mg

List Price:

$275.00

Datasheet
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