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The purity of Mouse IL6ST /GP130 /CD130 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of Mouse IL6ST /GP130 /CD130 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

CD130 Recombinant Protein

CATALOG NUMBER: 96-478

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Mouse
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 23 - Glu 617
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
68.5 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
Il6st
Additional Names:
IL6ST, gp130, CD130, IL-6RB, IL-6R-beta, CDw130
Protein Accession Number:
NP_034690
Ncbi Gene Id Number:
16195
Background:
Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
Background Reference 1:
Saito M., et al., 1992, J. Immunol. 148:4066-4071. (2) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386. (3) Tanaka M., et al., 1999, Blood 93:804-815.
Background Reference 2:
Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
Background Reference 3:
Tanaka M., et al., 1999, Blood 93:804-815.

FOR RESEARCH USE ONLY

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Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-478

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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