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CD154 Antibody [MR1] (PE)

CATALOG NUMBER: 76-870

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
PE
Specifications
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Armenian Hamster IgG
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Cd40lg
Additional Names:
IGM, IMD3, Ly62, TRAP, gp39, CD154, Cd40l, HIGM1, Ly-62, T-BAM, CD40-L, Tnfsf5, Cd40lg
Ncbi Gene Id Number:
21947
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39. CD154 is expressed on activated T cells and plays a role in B-T cell costimulation. The interaction of CD154 with CD40 induces B cell cycle entry and the signaling for T-dependent B cell activation. By interfering with this interaction, the MR1 antibody is reported to inhibit T and B lymphocyte activation.
Background Reference 1:
Frster, R., Kremmer, E., Schubel, A., Breitfeld, D., Kleinschmidt, A., Nerl, C., ... Lipp, M. (1998). Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation.The Journal of Immunology,160(3), 1522-1531.
Background Reference 2:
Schabath, R., M, G., Schubel, A., Kremmer, E., Lipp, M., Frster, R. (1999). The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation.Journal of leukocyte biology,66(6), 996-1004.
Background Reference 3:
Gupta, S. K., Lysko, P. G., Pillarisetti, K., Ohlstein, E., Stadel, J. M. (1998). Chemokine Receptors in Human Endothelial Cells FUNCTIONAL EXPRESSION OF CXCR4 AND ITS TRANSCRIPTIONAL REGULATION BY INFLAMMATORY CYTOKINES.Journal of Biological Chemistry,273(7), 4282-4287.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-870

List Size:
0.025 mg

List Price:

$217.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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