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CD178 Antibody [NOK-1]

CATALOG NUMBER: 76-935

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IP, WB
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IP, WB
Specificity:
The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
FASLG
Additional Names:
APTL, FASL, CD178, CD95L, ALPS1B, CD95-L, TNFSF6, APT1LG1, FASLG
Ncbi Gene Id Number:
356
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.
Background Reference 1:
Kayagaki, N., Kawasaki, A., Ebata, T., Ohmoto, H., Ikeda, S., Inoue, S., ... Yagita, H. (1995). Metalloproteinase-mediated release of human Fas ligand.The Journal of experimental medicine,182(6), 1777-1783.
Background Reference 2:
Oyaizu, N., Adachi, Y., Hashimoto, F., McCloskey, T. W., Hosaka, N., Kayagaki, N., ... Pahwa, S. (1997). Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.The Journal of Immunology,158(5), 2456-2463.
Background Reference 3:
Villunger, A., Egle, A., Marschitz, I., Kos, M., Bck, G., Ludwig, H., ... Greil, R. (1997). Constitutive expression of Fas (Apo-1/CD95) ligand on multiple myeloma cells: a potential mechanism of tumor-induced suppression of immune surveillance.Blood,90(1), 12-20.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-935

List Size:
0.1 mg

List Price:

$391.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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