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CD2 Antibody [RM2-5]

CATALOG NUMBER: 76-187

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow
Specificity:
The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Rat IgG2b, lambda
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Cd2
Additional Names:
Ly37, LFA-2, Ly-37, Cd2
Ncbi Gene Id Number:
12481
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein. CD2 is expressed on B cells, T cells, NK cells, and thymocytes and its ligand is CD48. It may be involved in immunoregulation, thymocyte maturation, and T-cell activation. The RM2-5 antibody has been reported to block CD2 mediated cell to cell adhesion.
Background Reference 1:
Yagita, H., Nakamura, T., Karasuyama, H., Okumura, K. (1989). Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.Proceedings of the National Academy of Sciences,86(2), 645-649.
Background Reference 2:
Nakamura, T. E. T. S. U. Y. A., Takahashi, K. A. Z. U. H. I. S. A., Fukazawa, T. O. H. R. U., Koyanagi, M. A. K. O. T. O., Yokoyama, A., Kato, H., ... Okumura, K. (1990). Relative contribution of CD2 and LFA-1 to murine T and natural killer cell functions.The Journal of Immunology,145(11), 3628-3634.
Background Reference 3:
Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y. W., Williams, A. F., ... Yagita, H. (1992). CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation.The Journal of experimental medicine,176(5), 1241-1249.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-187

List Size:
0.1 mg

List Price:

$302.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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