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Human peripheral blood lymphocytes were stained with FITC RPA-2.10 with relevant isotype control in Red.
Human peripheral blood lymphocytes were stained with FITC RPA-2.10 with relevant isotype control in Red.

CD2 Antibody [RPA-2.10]

CATALOG NUMBER: 76-186

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
CD2
Additional Names:
T11, SRBC, LFA-2, CD2
Ncbi Gene Id Number:
914
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..
Background Reference 1:
Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 2:
Hahn, W. C., Burakoff, S. J., Bierer, B. E. (1993). Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58.The Journal of Immunology,150(7), 2607-2619.
Background Reference 3:
Aversa, G. G., Bishop, G. A., Suranyi, M. G., Hall, B. M. (1987, February). RPA-2.10: an anti-CD2 monoclonal antibody that inhibits alloimmune responses and monitors T cell activation. InTransplantation proceedings(Vol. 19, No. 1 Pt 1, pp. 277-278).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-186

List Size:
0.5 mg

List Price:

$546.00

Datasheet
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