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Western blot analysis of extract from Raji cells using CD22 Antibody.
Western blot analysis of extract from Raji cells using CD22 Antibody.

CD22 Antibody

CATALOG NUMBER: 79-684

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
CD22 antibody was raised against a peptide sequence around aa.839~843 (N-V-D-Y-V) derived from Human CD22.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
This antibody detects endogenous level of total CD22 protein.
Predicted Molecular Weight:
140 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
physical-state:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
CD22
Additional Names:
SIGLEC2, SIGLEC-2, RAF, SIGLEC2, FLJ22814, MGC130020,
Protein Accession Number:
NP_001762.2
Protein Gi Number:
157168355
Ncbi Gene Id Number:
933
Background:
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Background Reference 1:
Doody G. M., Justement L. B., Delibrias C. C., Matthews R. J., Lin J., Thomas M. L., Fearon D. T. Science 269:242-244 (1995) Tuscano J. M., Engel P., Tedder T. F., Agarwal A., Kehrl J. H. Eur. J. Immunol. 26:1246-1252 (1996) Law C. L., Sidorenko S. P., Chandran K. A., Zhao Z., Shen S. H., Fischer E. H., Clark E. A. J. Exp. Med. 183:547-560 (1996)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-684

List Size:
0.1 mg

List Price:

$370.00

Datasheet
Shipping Info

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$35 Dry Ice Shipment fee may be required on some items.

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