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CD243 Antibody [UIC2] (PE)

CATALOG NUMBER: 76-952

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
PE
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG2a
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
ABCB1
Additional Names:
CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170, ABCB1
Ncbi Gene Id Number:
5243
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp). It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.
Background Reference 1:
Tseng, S. Y., Otsuji, M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., ... Tsuchiya, H. (2001). B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.The Journal of experimental medicine,193(7), 839-846.
Background Reference 2:
Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T., Chen, L. (2003). Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.The Journal of experimental medicine,197(9), 1083-1091.
Background Reference 3:
Aramaki, O., Shirasugi, N., Takayama, T., Shimazu, M., Kitajima, M., Ikeda, Y., ... Niimi, M. (2004). Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen.Transplantation,77(1), 6-12.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-952

List Size:
100 tests

List Price:

$540.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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