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CD243 Antibody [UIC2] (PE)

CATALOG NUMBER: 76-953

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
PE
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG2a
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
ABCB1
Additional Names:
CLCS, MDR1, P-GP, PGY1, ABC20, CD243, GP170, ABCB1
Ncbi Gene Id Number:
5243
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The UIC2 monoclonal antibody specifically reacts with CD243, a 170 kDA transmembrane protein also known as human multidrug resistant-1 (MDR-1) or P-glycoprotein (Pgp). It is an ATP binding cassette (ABC) transport and is expressed on B, T, NK cells to the exclusion of monocytes. CD243 is involved in the process that transports molecules across the cellular membranes and plays a role in multidrug resistance. The UIC2 antibody inhibits CD243 mediated efflux.
Background Reference 1:
Matsumoto, M., Kikkawa, S., Kohase, M., Miyake, K., Seya, T. (2002). Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.Biochemical and biophysical research communications,293(5), 1364-1369.
Background Reference 2:
Schreiner, B., Voss, J., Wischhusen, J., Dombrowski, Y., Steinle, A., Lochm, H., ... Wiendl, H. (2006). Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands.The FASEB journal,20(1), 118-120.
Background Reference 3:
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T., Seya, T. (2003). TICAM-1, an adaptor molecule that participates in Toll-like receptor 3mediated interferon--beta- induction.Nature immunology,4(2), 161-167.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-953

List Size:
25 tests

List Price:

$285.00

Out of stock

Datasheet
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