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CD252 Antibody [RM134L] (APC)

CATALOG NUMBER: 76-943

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
APC
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
APC
Tested Applications:
Flow
Specificity:
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2b, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Tnfsf4
Additional Names:
Ath1, gp34, Ath-1, Ox40l, TXGP1, CD134L, OX-40L, Txgp1l, Tnfsf4
Ncbi Gene Id Number:
22164
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.
Background Reference 1:
Otsuki, N., Kamimura, Y., Hashiguchi, M., Azuma, M. (2006). Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells.Biochemical and biophysical research communications,344(4), 1121-1127.
Background Reference 2:
Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., ... Murphy, K. M. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.Nature immunology,4(7), 670-679.
Background Reference 3:
Sedy, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K., ... Murphy, K. M. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.Nature immunology,6(1), 90-98.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-943

List Size:
0.1 mg

List Price:

$365.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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