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CD27 Antibody [LG.3A10]

CATALOG NUMBER: 76-630

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Hamster
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Hamster
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The LG.3A10 monoclonal antibody binds to CD27, 45kDA molecule in the Tumor Necrosis Factor Receptor (TNFR) superfamily.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Armenian Hamster IgG
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Cd27
Additional Names:
S152, Tp55, Tnfrsf7, Cd27
Ncbi Gene Id Number:
21940
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The LG.3A10 monoclonal antibody binds to CD27, 45kDA molecule in the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on memory B cells, NK cells, mature T cells, and a subset of thymocytes. Cd27 is involved in the interactions between B and T cells through its ligand CD70. The LG.3A10 antibody is cross-reactive with human, mouse and rat CD27.
Background Reference 1:
Tesselaar, K., Xiao, Y., Arens, R., van Schijndel, G. M., Schuurhuis, D. H., Mebius, R. E., ... van Lier, R. A. (2003). Expression of the murine CD27 ligand CD70 in vitro and in vivo.The journal of immunology,170(1), 33-40.
Background Reference 2:
Lee, E. M., Hurh, S., Cho, B., Oh, K. H., Kim, S. U., Surh, C. D., ... Ahn, C. (2013). CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T cell death.Stem cell research therapy,4(3), 56.
Background Reference 3:
Gravestein, L. A., Nieland, J. D., Kruisbeek, A. M., Borst, J. (1995). Novel mAbs reveal potent co-stimulatory activity of murine CD27.International immunology,7(4), 551-557.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-630

List Size:
0.05 mg

List Price:

$249.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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