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CD28 Antibody [37.51]

CATALOG NUMBER: 76-741

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IP
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IP
Specificity:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Golden Syrian Hamster IgG
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Cd28
Additional Names:
CH29-189K17.3, Cd28
Ncbi Gene Id Number:
12487
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes, and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD 28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes.The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production.
Background Reference 1:
Tacke, M., Clark, G. J., Dallman, M. J., Hnig, T. (1995). Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.The Journal of Immunology,154(10), 5121-5127.
Background Reference 2:
Tacke, M., Hanke, G., Hanke, T., Hnig, T. (1997). CD28mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28.European journal of immunology,27(1), 239-247.
Background Reference 3:
Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation.Immunity,2(6), 555-559.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-741

List Size:
1 mg

List Price:

$627.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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