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Human CD28H, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.
Immobilized Human CD28H, His Tag at 5 ug/mL (100 uL/well) can bind Biotinylated Human B7-H7, Fc Tag, Avi Tag with a linear range of 10-156 ng/mL (QC tested).
Immobilized Human CD28H, His Tag at 5 ug/mL (100 uL/well) can bind Human B7-H7, Fc Tag with a linear range of 1-78 ng/mL (Routinely tested).
Human CD28H, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 90%.

CD28H / IGPR-1 Recombinant Protein

CATALOG NUMBER: 11-383

Tested Applications:
ELISA, WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Leu 23 - Gly 150
Fusion Tag:
His Tag
Tested Applications:
ELISA, WB
Application Note:
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 22-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight:
15.9 kDa
Purity:
>90% as determined by reduced SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
TMIGD2
Additional Names:
TMIGD2,IGPR1
Protein Accession Number:
AAH15655
Ncbi Gene Id Number:
126259
Background:
CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1,is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue,the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Background Reference 1:
Evans E.J., et al., 2005, Nat. Immunol. 6:271-279.
Background Reference 2:
Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46.
Background Reference 3:
Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

11-383

List Size:
0.1 mg

List Price:

$577.00

Datasheet
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