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CD335 Antibody [29A1.4] (PE)

CATALOG NUMBER: 76-982

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
PE
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2b, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Ncr1
Additional Names:
Ly94, NKp46, Ncr1
Ncbi Gene Id Number:
17086
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 29A1.4 antibody specifically reacts with CD335 (NKp46), a 46kDA natural cytotoxicity receptor family molecule. It is expressed in only NK and a rare subset of NK-like T cells, not including the CD1d-restricted NKT division. CD335 is active during NK lysis of pathogen-infected and tumor cells.The 29A1.4 in vitro activates NK cells, but does not deplete NK cells in vivo.
Background Reference 1:
Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., ... Sakaguchi, S. (2005). Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+ CD25+ CD4+ regulatory T cells.The Journal of experimental medicine,202(7), 885-891.
Background Reference 2:
Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., Sakaguchi, S. (2002). Stimulation of CD25+ CD4+ regulatory T cells through GITR breaks immunological self-tolerance.Nature immunology,3(2), 135-142.
Background Reference 3:
Tone, M., Tone, Y., Adams, E., Yates, S. F., Frewin, M. R., Cobbold, S. P., Waldmann, H. (2003). Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.Proceedings of the National Academy of Sciences,100(25), 15059-15064.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-982

List Size:
0.025 mg

List Price:

$259.00

Out of stock

Datasheet
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