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CD4 Antibody [RM4-5] (PE)

CATALOG NUMBER: 76-375

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
PE
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2a, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Cd4
Additional Names:
L3T4, Ly-4, Cd4
Ncbi Gene Id Number:
12504
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The RM4-5 monoclonal antibody specifically reacts with mouse CD4, also known as L3T4, a 55 kDa differentiation antigen expressed by the majority of thymocytes, subpopulations of mature T cells (like major histocompatibility complex class II-restricted T lymphocytes), a subset of natural killer T cells, and on pluripotent hematopoietic stem cells. CD4 binds to the major histocompatibility complex class II (MHC class II) and enhances T lymphocyte development and mature T cells functions. In T lymphocytes, CD4 binds to the cytoplasmic tail of enzyme tyrosine kinase (p56lck).Binding of RM4-5 is blocked by the anti-mouse CD4 clone GK1.5.
Background Reference 1:
Shevach, E. M. (2000). Regulatory T cells in autoimmmunity*.Annual review of immunology,18(1), 423-449.
Background Reference 2:
Wu, L., Scollay, R., Egerton, M., Pearse, M., Spangrude, G. J., Shortman, K. (1991). CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
Background Reference 3:
Bliss, S. K., Bliss, S. P., Beiting, D. P., Alcaraz, A., Appleton, J. A. (2007). IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.The Journal of Immunology,178(12), 7974-7983.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-375

List Size:
0.1 mg

List Price:

$217.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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