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Western blot analysis of lysate from human spleen tissue lysate, using CD40 Antibody at 1:1000.
Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis of lysate from human spleen tissue lysate, using CD40 Antibody at 1:1000.

CD40 Antibody

CATALOG NUMBER: 59-489

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Pig
Immunogen:
This CD40 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human CD40.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
31 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CD40
Additional Names:
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, CD40, CD40, TNFRSF5
Protein Accession Number:
P25942
Protein Gi Number:
116000
Ncbi Gene Id Number:
958
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a member of theTNF-receptor superfamily. This receptor has been found to beessential in mediating a broad variety of immune and inflammatoryresponses including T cell-dependent immunoglobulin classswitching, memory B cell development, and germinal centerformation. AT-hook transcription factor AKNA is reported tocoordinately regulate the expression of this receptor and itsligand, which may be important for homotypic cell interactions.Adaptor protein TNFR2 interacts with this receptor and serves as amediator of the signal transduction. The interaction of thisreceptor and its ligand is found to be necessary foramyloid-beta-induced microglial activation, and thus is thought tobe an early event in Alzheimer disease pathogenesis. Twoalternatively spliced transcript variants of this gene encodingdistinct isoforms have been reported.
Background Reference 1:
Rodriguez-Rodriguez, L., et al. J. Rheumatol. 37(10):2076-2080(2010)
Background Reference 2:
Lewis, J.P., et al. Genomics 96(4):211-219(2010)
Background Reference 3:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 4:
Blanco-Kelly, F., et al. PLoS ONE(7), E11520 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-489

List Size:
400 ul

List Price:

$495.00

Datasheet
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