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CD45 Antibody [HI30]

CATALOG NUMBER: 76-440

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, ICC, IHC, IP, WB
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, ICC, IHC, IP, WB
Specificity:
The HI30 monoclonal antibody specifically reacts with the 180 kDa, 190 kDa, 205 kDa, and 220 kDa isoforms of the human leukocyte common antigen (LCA) CD45.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
PTPRC
Additional Names:
LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180, PTPRC
Ncbi Gene Id Number:
5788
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The HI30 monoclonal antibody specifically reacts with the 180 kDa, 190 kDa, 205 kDa, and 220 kDa isoforms of the human leukocyte common antigen (LCA) CD45. It is expressed on lymphocytes, granulocytes, monocytes, thymocytes, and eosinophils, but not on mature erythrocytes, platelets, mature erythroid cells of bone marrow, and non-hematopoietic tissues. CD45 is essential for T cell activation and the tyrosine phosphatase activity of its intracellular region is integral for signal transduction.
Background Reference 1:
Knapp W(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 2:
Ninomiya, M., Abe, A., Katsumi, A., Xu, J., Ito, M., Arai, F., ... Naoe, T. (2006). Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice.Leukemia,21(1), 136-142.
Background Reference 3:
Yoshino, N., AMI, Y., TERAO, K., TASHIRO, F., HONDA, M. (2000). Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.Experimental Animals,49(2), 97-110.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-440

List Size:
0.1 mg

List Price:

$217.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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