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CD49b Antibody [HMa2]

CATALOG NUMBER: 76-808

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Armenian Hamster IgG
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
Itga2
Additional Names:
DX5, CD49B, Itga2
Ncbi Gene Id Number:
16398
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1). VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.
Background Reference 1:
Baron, J. L., Reich, E. P., Visintin, I., Janeway Jr, C. A. (1994). The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.Journal of Clinical Investigation,93(4), 1700.
Background Reference 2:
Chisholm, P. L., Williams, C. A., Lobb, R. R. (1993). Monoclonal antibodies to the integrin alpha 4 subunit inhibit the murine contact hypersensitivity response.European journal of immunology,23(3), 682-688.
Background Reference 3:
Holzmann, B., McIntyre, B. W., Weissman, I. L. (1989). Identification of a murine Peyer's patchspecific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4alpha .Cell,56(1), 37-46.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-808

List Size:
0.5 mg

List Price:

$540.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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