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CD49d Antibody [9F10] (APC)

CATALOG NUMBER: 76-805

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
APC
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
APC
Tested Applications:
Flow
Specificity:
The 9F10 monoclonal antibody specifically reacts with human CD49d, the 150 kDA alpha 4 integrin chain.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
ITGA4
Additional Names:
IA4, CD49D, ITGA4
Ncbi Gene Id Number:
3676
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 9F10 monoclonal antibody specifically reacts with human CD49d, the 150 kDA alpha 4 integrin chain. The molecule forms the heterodimer called VLA-4 with integrin beta 1 and another heterodimer with integrin beta 7 that binds fibronectin, VCAM-1, and MadCAM-1. CD49d is expressed on monocytes, lymphocytes, thymocytes, NK cells, B cells, and T cells. It is involved in hematopoietic stem cell differentiation, cell migration, and cell activation. Its absence on Foxp3+ cells make it a useful marker to isolate Treg cell populations.
Background Reference 1:
Arase, H., Saito, T., Phillips, J. H., Lanier, L. L. (2001). Cutting edge: the mouse NK cell-associated antigen recognized by DX5 moncoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2).The Journal of Immunology,167(3), 1141-1144.
Background Reference 2:
Miyake, S., Sakurai, T., Okumura, K., Yagita, H. (1994). Identification of collagen and laminin receptor integrins on murine T lymphocytes.European journal of immunology,24(9), 2000-2005.
Background Reference 3:
Noto, K., Kato, K., Okumura, K., Yagita, H. (1995). Identification and functional characterization of mouse CD29 with a mAb.International immunology,7(5), 835-842.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-805

List Size:
100 tests

List Price:

$455.00

Out of stock

Datasheet
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