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CD54 Antibody [15.2]

CATALOG NUMBER: 76-431

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IHC, WB
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IHC, WB
Specificity:
The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgG1
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
ICAM1
Additional Names:
BB2, CD54, P3.58, ICAM1
Ncbi Gene Id Number:
3383
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 15.2 antibody reacts with the 85-110 kDa intracellular adhesion molecule-1 (ICAM-1), a member of the Ig superfamily which acts as a ligand for the Lymphocyte Function-Associated Antigen-1 (LFA-1). ICAM-1 is also known CD 54 and is expressed on non-hematopoietic cells of vascular endothelial, thymic epithelial, fibroblasts lineages, and on hematopoietic cells like macrophages, mitogen-stimulated T-lymphoblasts, dendritic cells in tonsils, lymph nodes and Peyer’s patches, and germinal center B cells.Inflammatory mediators (IL-1, TNF, IFN-gamma) enhance the production of ICAM-1 on fibroblasts and endothelial cells within few hours. Thus, ICAM-1 seems to be the marker of inflammatory reactions.
Background Reference 1:
Bhattacharya, A. L. O. K., Dorf, M. E., Springer, T. A. (1981). A shared alloantigenic determinant on Ia antigens encoded by the IA and IE subregions: evidence for I region gene duplication. The Journal of Immunology,127(6), 2488-2495.
Background Reference 2:
Mendiratta, S. K., Singh, N., Bal, V., Rath, S. (1996). Analysis of T-cell hybridomas with an unusual MHC class II-dependent ligand specificity.Immunology,89(2), 238-244.
Background Reference 3:
Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., Mellman, I. (2007). The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.Proceedings of the National Academy of Sciences,104(1), 234-239.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-431

List Size:
0.5 mg

List Price:

$627.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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