CD62P Antibody [Psel.KO2.3] (PE)

CATALOG NUMBER: 76-210

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Human, Mouse
Conjugate:
PE
Specifications
Host Species:
Mouse
Species Reactivity:
Human, Mouse
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
SELP
Additional Names:
CD62, GRMP, PSEL, CD62P, GMP140, LECAM3, PADGEM, Lnhr, CD62L, Ly-22, Lyam1, Ly-m22, Lyam-1, LECAM-1, AI528707, L-selectin, SELP
Ncbi Gene Id Number:
6403;20344
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The Psel.KO2.3 monoclonal antibody specifically reacts with mouse CD62P (P-Selectin), a 140 kDA type I transmembrane glycoprotein also known as granule membrane protein 140 (GMP-140). Upon activation it is quickly transported to the plasma membrane from the alpha-granules of platelets and WEibel-Palade bodies of endothelial cells. It is essential to the functions of cell adhesion during inflammatory reactions and in the interaction of platelets with monocytes and neutrophils. The Psel.KO2.3 antibody does not block adhesion and binds to an epitope common to several species including mouse, human, and rat.
Background Reference 1:
Massaguer, A., Engel, P., PrezdelPulgar, S., Bosch, J., Pizcueta, P. (2000). Production and characterization of monoclonal antibodies against conserved epitopes of Pselectin (CD62P).Tissue antigens,56(2), 117-128.
Background Reference 2:
Kansas, G. S. (1996). Selectins and their ligands: current concepts and controversies.Blood,88(9), 3259-3287.
Background Reference 3:
Bullard, D. C., Kunkel, E. J., Kubo, H., Hicks, M. J., Lorenzo, I., Doyle, N. A., ... Beaudet, A. L. (1996). Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice.The Journal of experimental medicine,183(5), 2329-2336.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-210

List Size:
0.025 mg

List Price:

$249.00

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